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. 2012 Oct 31;7(10):e48451. doi: 10.1371/journal.pone.0048451

Figure 4. Observation of EGFP-positive AT2s and AT1s in TMX-treated transgenic mice after influenza virus infection. A–E.

Figure 4

Representative images of lung sections of TMX-treated Scgb1a1-CreER:ACTB-mT-EGFP transgenic mice after (at 21 dpi) (A–C) and before (D–E) influenza infection. Expression of EGFP (green), tomato red (purple) and pro-SPC (red) are analyzed in (A, B, D, E). Higher magnification images of selected areas in (A) and (D) are shown as (B) and (E), respectively. White broken line in (A) demarcates the infiltrated area (below) and normal area (above). Expression of EGFP (green) and PDPN (red) with DAPI (blue) staining are analyzed in (C). Arrows in (E) indicate EGFP and PDPN double-positive cells. Scale bars: (A, D) 500 µm; (B, E) 100 µm; (C) 20 µm.