Table 1. Aggregation of SOD1 mutants in transfected cells.
SOD1 Construct | Production of inclusions in 24 h | # of cells with YFP counted | # of cells with inclusions | # of condensed cells |
WT | − | 128 | 0 (0%) | 9 (7%) |
A4V | + | 314 | 83 (27%) | 36 (11%) |
C111Y | + | 850 | 252 (29%) | 68 (8%) |
C111S | − | 747 | 0 (0%) | 142 (19%) |
C6G/C111Y | + | 632 | 43 (6%) | 50 (8%) |
C6G/C111S | − | 898 | 0 (0%) | 106 (12%) |
FSYR | + | 229 | 117 (51%) | 13 (6%) |
GSYR | + | 257 | 36 (14%) | 21 (8%) |