Table 3. Multivariate analysis of the influence of HPV 16/18 expression and IL-10 mRNA expression on overall survival (OS) and relapse free survival (RFS) in oral cancer patients.
| Parameter | Case No. | OS | RFS | ||||||
| 5-year survival (%) | HR | 95% CI | P | 5-year survival (%) | HR | 95%CI | P | ||
| IL-10 | |||||||||
| Low | 89 | 67.4 | 1.000 | Referent | 45.7 | 1.000 | Referent | ||
| High | 89 | 47.2 | 2.438 | 1.345–4.419 | 0.003 | 29.9 | 2.098 | 1.329–3.311 | 0.001 |
| HPV | |||||||||
| Negative | 84 | 72.6 | 1.000 | Referent | 49.2 | 1.000 | Referent | ||
| Positive | 94 | 46.3 | 1.765 | 0.790–3.945 | 0.166 | 27.2 | 1.604 | 0.847–3.038 | 0.147 |
| HPV negative | |||||||||
| IL-10 Low | 55 | 68.4 | 1.000 | Referent | 48.0 | 1.000 | Referent | ||
| IL-10 High | 29 | 68.7 | 1.323 | 0.521–3.361 | 0.556 | 53.1 | 1.237 | 0.610–2.507 | 0.555 |
| HPV positive | |||||||||
| IL-10 Low | 34 | 70.8 | 1.000 | Referent | 47.0 | 1.000 | Referent | ||
| IL-10 High | 60 | 28.7 | 4.810 | 1.946–11.892 | 0.001 | 0.0 | 3.807 | 1.771–8.184 | 0.001 |
The interaction between HPV and IL-10: χ2 = 2.675, df = 1, P = 0.102 for OS; χ2 = 2.781, df = 1, P = 0.095 for RFS.