Table 4. Multivariate analysis of the influence of various parameters on overall survival (OS) and relapse free survival (RFS) in oral cancer patients according to gender.
| Parameter | Category | Case No. | OS | RFS | ||||||
| 5-year survival (%) | HR | 95% CI | P | 5-year survival (%) | HR | 95%CI | P | |||
| Female | ||||||||||
| Stage | III+IV/I+II | 25/45 | 36.3/72.0 | 3.393 | 1.389–8.289 | 0.007 | 10.6/58.3 | 2.844 | 1.441–5.614 | 0.003 |
| HPV | Positive/Negative | 56/14 | 51.9/83.9 | 1.715 | 0.484–6.081 | 0.404 | 26.9/84.6 | 3.764 | 1.111–12.749 | 0.033 |
| IL-10 | High/Low | 38/32 | 24.5/76.3 | 3.610 | 1.345–9.689 | 0.011 | 0.0/65.0 | 9.258 | 3.272–26.196 | <0.001 |
| Male | ||||||||||
| Stage | III+IV/I+II | 50/58 | 22.7/81.9 | 3.707 | 1.622–8.471 | 0.002 | 0.0/60.3 | 4.017 | 2.112–7.641 | <0.001 |
| HPV | Positive/Negative | 38/70 | 52.3/62.2 | 1.170 | 0.553–2.475 | 0.682 | 32.3/37.5 | 1.020 | 0.563–1.847 | 0.948 |
| IL-10 | High/Low | 51/57 | 60.5/60.4 | 2.140 | 1.002–4.571 | 0.049 | 51.5/30.7 | 1.309 | 0.741–2.314 | 0.354 |
| Non-smoker | ||||||||||
| Stage | III+IV/I+II | 24/49 | 35.8/74.0 | 2.791 | 1.108–7.031 | 0.029 | 5.9/58.5 | 2.459 | 1.200–5.036 | 0.014 |
| HPV | Positive/Negative | 53/20 | 53.8/77.9 | 0.732 | 0.213–2.517 | 0.620 | 27.9/63.8 | 0.988 | 0.376–2.596 | 0.981 |
| IL-10 | High/Low | 39/34 | 32.1/75.9 | 3.121 | 1.011–9.635 | 0.048 | 0.0/60.6 | 5.894 | 2.081–16.695 | 0.001 |
| Smoker | ||||||||||
| Stage | III+IV/I+II | 51/54 | 30.2/81.8 | 3.953 | 1.671–9.351 | 0.002 | 10.9/69.2 | 3.460 | 1.816–6.592 | <0.001 |
| HPV | Positive/Negative | 64/41 | 50.0/71.1 | 1.279 | 0.595–2.748 | 0.528 | 31.1/51.9 | 1.121 | 0.612–2.052 | 0.712 |
| IL-10 | High/Low | 50/55 | 56.1/55.1 | 2.497 | 1.160–5.373 | 0.019 | 46.8/31.9 | 1.428 | 0.803–2.539 | 0.225 |
| Non-drinker | ||||||||||
| Stage | III+IV/I+II | 38/61 | 39.8/78.9 | 4.206 | 1.828–9.679 | 0.001 | 13.8/66.9 | 3.692 | 1.994–6.841 | <0.001 |
| HPV | Positive/Negative | 64/35 | 55.9/77.1 | 1.335 | 0.480–3.711 | 0.579 | 33.6/61.5 | 1.290 | 0.614–2.710 | 0.502 |
| IL-10 | High/Low | 47/52 | 45.5/75.9 | 2.995 | 1.292–6.939 | 0.011 | 23.5/59.0 | 2.643 | 1.389–5.029 | 0.003 |
| Drinker | ||||||||||
| Stage | III+IV/I+II | 37/42 | 21.9/76.4 | 2.902 | 1.178–7.151 | 0.021 | 0.0/33.1 | 2.952 | 1.434–6.075 | 0.003 |
| HPV | Positive/Negative | 30/49 | 57.4/53.1 | 1.083 | 0.437–2.686 | 0.864 | 12.8/18.1 | 1.252 | 0.608–2.578 | 0.542 |
| IL-10 | High/Low | 42/37 | 52.7/48.7 | 1.760 | 0.721–4.297 | 0.215 | 41.4/13.5 | 1.397 | 0.696–2.806 | 0.347 |
| Non-betel quid chewer | ||||||||||
| Stage | III+IV/I+II | 34/46 | 34.3/64.2 | 3.523 | 1.446–8.583 | 0.006 | 11.0/64.7 | 2.911 | 1.456–5.818 | 0.003 |
| HPV | Positive/Negative | 60/20 | 51.3/68.0 | 0.598 | 0.192–1.864 | 0.376 | 27.3/70.9 | 1.238 | 0.459–3.341 | 0.673 |
| IL-10 | High/Low | 40/40 | 25.9/70.2 | 5.395 | 1.886–15.431 | 0.002 | 0.0/58.1 | 7.002 | 2.640–18.571 | <0.001 |
| Betel quid chewer | ||||||||||
| Stage | III+IV/I+II | 41/57 | 27.3/81.6 | 3.118 | 1.322–7.356 | 0.009 | 0.0/54.6 | 3.459 | 1.819–6.579 | <0.001 |
| HPV | Positive/Negative | 34/64 | 60.4/63.8 | 1.274 | 0.552–2.942 | 0.570 | 41.2/35.7 | 1.160 | 0.609–2.212 | 0.650 |
| IL-10 | High/Low | 49/49 | 61.6/64.9 | 1.871 | 0.815–5.296 | 0.140 | 48.2/30.8 | 1.075 | 0.582–1.986 | 0.816 |