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. 2012 Oct 31;7(10):e48102. doi: 10.1371/journal.pone.0048102

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© 2012 Pott et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A) Grouping of PPARG/RXR targets genes in human macrophages based on PPARG binding in mouse. Displayed is the number of genes that are human-specific, indirectly, and directly shared PPARG/RXR target genes. Only PPARG binding sites in proximity to genes (<100 kb to TSS) were taken into consideration. B) and C) Enrichment of PPARG binding in homologous regions proximal to SLAMF9/Slamf9 and NR1H3/Nr1h3 in human and mouse macrophages (upper and lower panel, respectively). SLAMF9/Slamf9 represents an indirectly shared PPARG target gene while NR1H3/Nr1h3 represents a directly shared target gene. Browser tracks for mouse are shown in reversed direction to facilitate easier comparison between human and mouse.