Figure 3. The influence of different Ca²⁺ flows on CASs.

By inhibiting CICR (dashed triangle), the frequency (A) and amplitude (B) of CASs decrease, but the duration (C) increases. CASs do not occur when CICR is inhibited more than 95%. By inhibiting SERCA (dashed circle), the frequency (A) of CASs increases, but both the amplitude (B) and the duration (C) decrease. CASs do not occur when SERCA is inhibited more than 70%. Inhibiting VGCCs (solid star) has little effect on the amplitude (B) and duration (C) but great on frequency (A) before CASs disappear. CASs do not occur when VGCCs are inhibited more than 45%.