Table 2. Genetic polymorphisms associated with lipid response to fenofibrate therapy in GOLDN (n = 861) and HyperTG (n = 267).
| SNP (Variant Allele) | Locus | F | Discovery P-value | Replication P-value | Direction of Association Discovery/Replication |
| High-density lipoprotein cholesterol | |||||
| rs964184 (G) | APOA1 | 19.8 | <0.0001 | 0.04 | Increase/Increase |
| rs7134375 (A) | PDE3A | 9.3 | 0.002 | 0.75 | Increase/NS |
| Low-density lipoprotein cholesterol | |||||
| rs3764261 (A) | CETP | 12.9 | 0.0004 | 0.38 | Decrease/NS |
| rs4420638 (G) | APOE | 10.4 | 0.001 | 0.10 | Increase/NS |
| rs964184 (G) | APOA1 | 10.1 | 0.002 | 0.42 | Increase/NS |
| rs2642442 (C) | MOSC1 | 4.8 | 0.03 | 0.25 | Decrease/NS |
| rs10401969 (C) | CILP2 | 4.1 | 0.04 | 0.64 | Decrease/NS |
| Total cholesterol | |||||
| rs3764261 (A) | CETP | 7.3 | 0.007 | 0.19 | Decrease/NS |
| rs4420638 (G) | APOE | 6.9 | 0.009 | 0.18 | Increase/NS |
| rs492602 (G) | FLJ36070 | 6.1 | 0.01 | 0.41 | Decrease/NS |
| rs10401969 (C) | CILP2 | 4.9 | 0.03 | 0.99 | Decrease/NS |
| Triglycerides | |||||
| rs964184 (G) | APOA1 | 15.3 | 0.0001 | 0.05 | Increase/Increase |