. Author manuscript; available in PMC: 2013 Sep 18.

Published in final edited form as: Biochemistry. 2012 Sep 4;51(37):7225–7238. doi: 10.1021/bi300894z

TABLE 2.

Residues and secondary structural elements located at the entrance channels in P450 2B4 and P450 2B6 are shown along with the corresponding residues in P450 2C9 proposed previously.

Channel	Residues Lining the access channels in corresponding P450s			Secondary Structure
	P4502B4	P450 2B6	P450 2C9
Solvent	S207, E301, R308, V477	S207, E301, R308, V477	C206, E300, R307, F476	E, F, I helices, β₄ sheet
2f	P38, L43, M46, R48, F212, V216, L219, G222	P38, L43, M46, R48, V212, L216, L219, G222	P37, I42, I45, I47, I215, N218, P211, P221	F’, G’ helices, A’, A helices
2a	L70, R73, A102, S221, G222	L70, R73, A102, S221, G222	K69, K72, P101, S220, P221	F’, G’ helices, β1 sheets