Table 1.

Key terms and definitions, as used in this review

Term	Definition
Anterograde/retrograde spread	Transneuronal spread of infectious virions across synaptically connected neurons in a circuit
Anterograde transport	Trafficking of the structural components of a virion, including capsid, tegument, and glycoproteins, down an axon along microtubules in a plus-end-directed manner toward the axon terminus
Retrograde transport	Transport of an infecting capsid in a minus-end-directed manner within axons toward the soma
Virion	Infectious unit of an alphaherpes virus, consisting of a capsid surrounded by tegument, surrounded by a host-derived lipid bilayer containing viral glycoproteins
Transport vesicle	A host-derived vesicle capable of associating with microtubule motors and transporting cargo in its lumen
Particle	Any of the structures that exist during the alphaherpes virus life cycle (entry through assembly and egress) including:
	1. Naked capsids
	2. Virions resident in the lumen of a transport vesicle
	3. L-particles resident in the lumen of a transport vesicle
	4. Empty transport vesicles containing viral glycoproteins