Fig. 1.

TENOR study design [15•]. Adapted from Chipps et al. 2012 [15•]; copyright (2012), with permission from Elsevier. Asterisk, daily high doses of inhaled steroids were defined by the American Thoracic Society refractory asthma guidelines for adults [37] and by the 1997 National Heart Lung and Blood Institute (NHLBI) guidelines for children [12]