Table 2.

Outcomes measured in systemic antibiotic treatment as an adjunctive therapy in scaling and root planing.

Clinical and microbiological outcomes	Caton et al. 2000 [10]	Golub et al. 2001 [7]	Novak et al. 2002 [11]	Preshaw et al. 2004 [12]	Preshaw et al. 2008 [18]	Guerrero et al. 2005 [14]	Reinhardt et al. 2007 [15]	Needleman et al. 2007 [16]	Griffiths et al. 2011 [17]
(1) CAL gain	∗	∗	∗	∗	∗	∗	∗	∗	∗
(2) PD reduction	∗	∗	∗	∗	∗	∗	∗	∗	∗
(3) % of BOP	∗		∗	∗	∗	∗	∗	∗
(4) Adverse events				∗		∗
(5) Gingival inflammation index		∗	∗
(6) Plaque index									∗
(7) Metabolic activity in GCF		∗						∗
(8) Proportion of spirochetes	∗
(9) Antibiotic sensitivity of microflora		∗

CAL: clinical attachment level; PD: probing depth; BOP: bleeding on probing depth; metabolic activity in GCF gingival crevicular fluid.