Fig. 1.

Talin2 protein is still expressed in current talin2 knockout mouse models. Western blotting for talin2 using the talin2-specific 68E7 monoclonal antibody [11] on brain and heart from wild-type (WT) male (M) and female (F) mice plus three Tln2 transgenic mouse lines; KO (exon1 deletion) [12]; GT4 (gene trap insertion in Tln2 coding sequence which generates a fusion protein containing the N-terminal half of talin2 fused to β-galactosidase [13], and SGT (gene trap insertion in 5′ UTR).