Figure 6.

Clonal Histogenesis

(A) The histogenesis of retina cells of different types derived from the live-imaging data.

(B) Matrix summarizing the cell composition of 197 DD divisions.

(C and D) The fate outcomes of the P progenitors of 59 PD divisions, 36 from cases in which the D cell was an RGC (C) and 23 in which it was an AC (D).

(E) Bar graph showing the proportions of the PD and DD divisions in generation of distinct cell fates.

(F) Bar graph showing the proportions of symmetric DD divisions (XX) and asymmetric DD divisions (XY) in generation of distinct cell fates.

(G) Illustration of compressing of single lineage tree into a barcode.

(H) Barcode cluster analysis of clones from (C) split into sister lineages (connected above), embedded into the smallest symmetric tree (inserting space as necessary), and converted into a barcode by a depth-first traversal to preserve structural units and hierarchically clustered according to Levenshtein distance (shown by the tree below). While sisters show similar sizes (due to their being born at the same time and place), there are no other obvious correlations between sister lineages.