Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Nov 1;2:156. doi: 10.3389/fonc.2012.00156

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

PMC Copyright notice

(A) EPA1–7 are located at subtelomeric loci in C. glabrata. The positions of seven EPA genes at their respective chromosome end loci are shown. EPA1 is furthest away from the telomere and is the only one that is expressed normally, while EPA 2–7 are usually silenced by TPE. Pink arrowheads, telomere repeats. (B) The telomere protein complex in budding yeast. Rap1 is the duplex telomere DNA binding factor, while Cdc13/Stn1/Ten1 binds to single-stranded telomere DNA. Rap1 recruits Sir3 and Sir4, which in turn recruits Sir2. Sir3 and Sir4 can also interact with histones directly. Sir2’s deacetylase activity maintains the hypoacetylated state of histones. Rap1 also recruits Rif1 and Rif2. Red stars, histone acetylation groups; green cylinders, nucleosomes.