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Loss of PTEN leads to hyperactivation of AKT in the nucleus of lymphoblast cells of CS patients. A, Whole-cell lysates were collected from lymphoblast cells isolated from two PTEN WT controls (control) and two Cowden syndrome patients harboring germline PTEN heterozygous R130X mutation (CS). Cell lysates were immunoblotted for PTEN and P-AKTSer473. B, Western blots of P-AKTSer473 expression in cytoplasmic/nuclear fractions of the lymphoblast cells.
