. 2012 Aug 9;97(11):3944–3950. doi: 10.1210/jc.2012-2481

Table 2.

Mean change in thyroid function between baseline (1992–1993) and CHS All-Stars (2005–2006) visits

	All participants (n = 657)			Disease-free reference population (n = 533)
	Baseline	Δ over time	% Δ	Baseline	Δ over time	% Δ
TSH (mU/liter)	2.6 (3.6)	0.34 (2.3)^a	+13%	2.3 (1.4)	0.28 (1.4)^a	+12%
FT4 (ng/dl)	1.2 (0.2)	0.02 (0.18)^a	+1.7%	1.2 (0.2)	0.03 (0.17)^a	+2.5%
Total T₃ (ng/dl)	116.9 (19.5)	−14.9 (20.8)^a	−13%	116.9 (19.5)	−14.9 (19.5)^a	−13%
TPOAb+ (%)	8.6	0.52	+6.0%

Baseline values are mean (sd) unless otherwise noted. All participants includes participants with values from both baseline and All-Stars examination reporting no thyroid hormone use at either visit. Disease-free reference population additionally excludes participants with overt hypo- or hyperthyroidism or TPOAb positivity at either visit. To convert FT4 to nanomoles per liter, multiply by 12.87. To convert total T₃ to nanomoles per liter, multiply by 0.0154.

P < 0.05.