Table 1.
Systemic and local estrogen concentrations in women with and without endometriosis
| Sample type | Hormonal status | n | E2 (pg/ml) |
E1 (pg/ml) |
E2/E1 ratio |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Median | 25/75% | P | Median | 25/75% | P | Median | 25/75% | P | |||
| Serum | |||||||||||
| Healthy | Proliferative | 9 | 77.1 | 48.0/110.0 | 59.3 | 48.1/77.0 | 1.37 | 0.97/1.81 | |||
| Secretory | 7 | 157.3 | 117.2/174.7 | # | 78.4 | 68.3/96.0 | 1.76 | 1.55/2.02 | |||
| Endometriosis | Proliferative | 19 | 68.7 | 52.1/195.0 | 63.4 | 49.1/90.8 | 1.46 | 0.89/1.98 | |||
| Secretory | 20 | 109.8 | 76.8/176.0 | 74.9 | 51.7/97.5 | 1.50 | 1.16/2.14 | ||||
| Medication | 21 | 2.5 | 2.5/58.6 | † | 21.3 | 16.6/96.1 | † | 0.13 | 0.12/0.80 | † | |
| Tissue | |||||||||||
| Healthy endometrium | Proliferative | 9 | 532.0 | 334.7/736.0 | 55.6 | 41.7/67.1 | 8.34 | 7.33/9.27 | |||
| Secretory | 7 | 66.0 | 52.5/100.8 | ## | 85.1 | 72.1/106.0 | # | 0.69 | 0.50/1.40 | ### | |
| Patient endometrium | Proliferative | 9 | 649.3 | 404.0/1168.7 | 57.3 | 44.0/152.8 | 8.64 | 4.72/13.11 | |||
| Secretory | 9 | 68.5 | 25.0/157.3 | ## | 117.6 | 61.1/194.7 | 0.80 | 0.69/0.99 | ### | ||
| Medication | 9 | 25.0 | 25.0/115.5 | 12.5 | 12.5/96.3 | 2.00 | 2.00/3.50 | † | |||
| Peritoneal endometrium | Proliferative | 3 | 238.0 | 78.9/397.0 | † | 55.1 | 43.3/96.5 | 5.50 | 0.82/7.21 | ||
| Secretory | 3 | 176.0 | 49.4/355.0 | 37.5 | 12.5/129.0 | 3.95 | 1.36/9.47 | ||||
| Medication | 3 | 25.0 | 25.0/25.0 | 12.5 | 12.5/32.8 | 2.00 | 0.76/2.00 | ||||
| Ovarian endometrium | Proliferative | 9 | 3430.0 | 1809.7/21600.0 | * | 1380.0 | 631.5/4280.0 | * | 4.35 | 1.69/5.53 | |
| Secretory | 9 | 305.0 | 199.0/758.0 | ## | 262.0 | 164.1/441.5 | ## | 1.34 | 1.04/3.28 | # | |
| Medication | 8 | 25.0 | 25.0/564.8 | † | 75.2 | 12.5/1709.0 | † | 2.00 | 0.62/2.58 | ||
| Deep endometrium | Proliferative | 8 | 112.0 | 53.9/162.0 | 74.3 | 36.7/194.0 | 1.06 | 0.60/2.60 | * | ||
| Secretory | 9 | 25.0 | 25.0/117.3 | 12.5 | 12.5/34.4 | ## | 2.00 | 1.44/4.77 | |||
| Medication | 8 | 38.5 | 25.0/115.6 | 23.4 | 12.5/128.8 | 2.00 | 0.65/2.00 | ||||
*
, P < 0.05 vs. PE within cycle phase.
†
, P < 0.05 vs. proliferative phase.
#, #, ###, P < 0.05, < 0.01, and < 0.001, respectively, vs. serum within the cycle phase.