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. 2012 Sep 20;97(11):E2063–E2069. doi: 10.1210/jc.2012-2275

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Copyright © 2012 by The Endocrine Society

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Fig. 2. — Effects of PDE11A4 variants expression on the dynamics of intracellular cAMP analyzed in living cells with FRET measurement. A, Representative traces of CFP/YFP ratio upon forskolin (1 μm) in HEK 293 cells transfected with the wild-type PDE11A (WT), and with the PDE11A variants (PDE11A4/M878V and PDE11A4/D609N). Forskolin application started at time zero and lasted 5 min. B, Average time course of the normalized CFP/YFP ratio upon forskolin (1 μm) stimulation in HEK293 transfected with the wild-type PDE11A cells (WT, n = 88), and in cells transfected with the PDE11A variants (PDE11A4/M878V, n = 73; and PDE11A4/D609N, n = 81). Forskolin application started at time zero and lasted 5 min. *, P < 0.0001.