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Effects of the PDE11A variants on cAMP-dependent transcription. The figure shows the activity of the CRE reporter construct 4x(CRE)-Luc in cells transfected with the PDE11A wild-type (WT) and the PDE11A4/M878V and PDE11A4/D609N expression vectors. A, Results obtained in HEK 293 cells; B, results obtained in H295R cells. *, P < 0.05; **, P < 0.003; ***, P < 0.0004.
