Table 2.
DXA regional aBMD and HRpQCT trabecular and cortical bone parameters of premenopausal (PRE) and postmenopausal (POST) women and all women combined
| All (n = 23) | PRE (n = 10) | POST (n = 13) | P value | |
|---|---|---|---|---|
| DXA regional aBMD | ||||
| FN (g/cm2) | 0.94 (0.80–1.06) | 1.07 (1.02–1.13) | 0.84 (0.77–0.94) | <0.001 |
| Spine L1-L4 (g/cm2) | 1.17 (1.00–1.29) | 1.26 (1.17–1.44) | 1.04 (0.94–1.07) | 0.004 |
| Total radius (g/cm2) | 0.62 (0.55–0.67) | 0.68 (0.65–0.72) | 0.58 (0.50–0.62) | <0.001 |
| Radius HRpQCT | ||||
| BV/TV | 0.122 (0.107–0.158) | 0.149 (0.127–0.165) | 0.108 (0.094–0.114) | 0.001 |
| TbN (1/mm) | 1.79 (1.53–2.03) | 1.97 (1.83–2.13) | 1.72 (1.43–1.79) | 0.005 |
| TbTh (mm) | 0.069 (0.063–0.076) | 0.074 (0.069–0.078) | 0.063 (0.060–0.069) | 0.011 |
| TbSp (mm) | 0.494 (0.416–0.585) | 0.434 (0.391–0.477) | 0.511 (0.499–0.646) | 0.003 |
| Conn Dens (1/mm3) | 2.64 (2.22–3.31) | 3.02 (2.57–3.60) | 2.44 (1.45–2.78) | 0.012 |
| SMI | 2.78 (2.10–2.98) | 2.55 (2.08–2.82) | 2.87 (2.68–3.22) | 0.088 |
| Ct vBMD (mg/cm3) | 964 (923–983) | 976 (930–984) | 952 (870–967) | 0.100 |
| CtTh (mm) | 0.94 (0.79–1.06) | 0.97 (0.93–1.12) | 0.89 (0.76–1.03) | 0.100 |
| EC (mm) | 49 (44–53) | 48 (44–53) | 49 (48–53) | 0.687 |
| PC (mm) | 67 (63–71) | 67 (63–71) | 67 (64–69) | 0.951 |
| CtPoV (mm3) | 7.1 (5.2–9.9) | 5.6 (3.3–7.9) | 9.6 (6.7–12.7) | 0.010 |
| CtPo (%) | 1.40 (0.89–2.26) | 0.89 (0.71–1.50) | 2.17 (1.34–2.45) | 0.005 |
| Stiffness, K (kN/mm) | 76 (59–86) | 78 (77–93) | 61 (59–75) | 0.007 |
| E (MPa) | 1,888 (1700–2076) | 2,055 (1,965–2,312) | 1,741 (1551–1888) | 0.008 |
| Failure load (n) | 3,771 (2,990–4,380) | 4,008 (3,935–4,689) | 3,020 (2,867–3,721) | 0.010 |
| Tibia HRpQCT | ||||
| BV/TV | 0.14 (0.121–0.157) | 0.154 (0.144–0.168) | 0.132 (0.108–0.140) | 0.011 |
| TbN (1/mm) | 1.82 (1.67–2.00) | 1.89 (1.81–2.17) | 1.78 (1.64–1.95) | 0.182 |
| TbTh (mm) | 0.081 (0.066–0.086) | 0.083 (0.077–0.093) | 0.070 (0.065–0.084) | 0.107 |
| TbSp (mm) | 0.474 (0.419–0.524) | 0.443 (0.381–0.474) | 0.497 (0.442–0.534) | 0.067 |
| Conn Dens (1/mm3) | 3.19 (2.82–4.03) | 3.42 (3.12–4.15) | 2.99 (2.82–3.37) | 0.182 |
| SMI | 1.55 (1.25–2.22) | 1.34 (1.18–1.89) | 1.72 (1.35–2.27) | 0.145 |
| Ct vBMD (mg/cm3) | 878 (823–945) | 945 (902–965) | 829 (811–866) | <0.001 |
| CtTh (mm) | 1.15 (0.99–1.34) | 1.31 (1.04–1.54) | 1.03 (0.99–1.20) | 0.077 |
| EC (mm) | 87 (84–93) | 88 (75–94) | 87 (85–92) | 0.733 |
| PC (mm) | 106 (101–112) | 107 (96–112) | 106 (103–111) | 0.852 |
| CtPoV (mm3) | 46.9 (35.1–62.1) | 35.9 (29.6–42.4) | 56.6 (52.8–66.8) | 0.007 |
| CtPo (%) | 5.15 (2.97–6.84) | 2.98 (2.48–4.32) | 6.46 (6.14–7.55) | 0.001 |
| Stiffness (kn/mm) | 191 (152–217) | 218 (207–248) | 172 (142–178) | 0.001 |
| E (MPa) | 2,042 (1,762–2359) | 2,366 (2,089–2,671) | 1,775 (1,727–2,033) | 0.001 |
| Failure load (n) | 9,575 (7,773–11,213) | 11,245 (10,164–12,376) | 8,598 (7,099–9,132) | 0.001 |
Data are shown as median (IQR).