Table 1.
Volunteer characteristics and nadir palmitate concentration and Ra during a MMTT and IVGTT
| Variable | Young |
Elderly |
P age | P sex | P interaction | ||
|---|---|---|---|---|---|---|---|
| Males | Females | Males | Females | ||||
| n | 31 | 29 | 83 | 57 | |||
| Age (yr) | 24 ± 3 | 22 ± 3 | 69 ± 6 | 70 ± 6 | |||
| BMI (kg/m2) | 25.0 ± 2.8 | 24.1 ± 2.8 | 27.5 ± 3.1 | 27.0 ± 3.5 | <0.001 | 0.175 | 0.745 |
| REE (kcal/d) | 1795 ± 300 | 1450 ± 164 | 1679 ± 209 | 1313 ± 155 | <0.001 | <0.001 | 0.374 |
| TG (mg/dl) | 105 ± 40 | 99 ± 37 | 120 ± 47 | 125 ± 54 | 0.008 | 0.772 | 0.399 |
| SIMeal [×10−4 dl/kg min−1/(μU/ml)] | 15.8 ± 10.0 | 8.7 ± 5.0 | 9.4 ± 6.8 | 8.1 ± 6.0 | 0.002 | 0.001 | 0.048 |
| SIIVGTT [×10−4 dl/kg min−1/(μU/ml)] | 6.7 ± 3.1 | 5.0 ± 2.3 | 3.6 ± 2.3 | 4.2 ± 2.8 | <0.001 | 0.396 | 0.024 |
| VAT (kg) | 2.2 ± 1.2 | 1.5 ± 0.8 | 4.7 ± 1.9 | 3.8 ± 1.7 | <0.001 | 0.002 | 0.888 |
| UBSQ (kg) | 8.6 ± 3.2 | 11.1 ± 3.7 | 11.4 ± 3.6 | 14.5 ± 3.7 | <0.001 | <0.001 | 0.537 |
| VO2 max (ml/kg FFM/min) | 58.82 ± 8.60 | 56.39 ± 8.45 | 40.64 ± 6.79 | 38.39 ± 6.92 | <0.001 | 0.046 | 0.934 |
| Meal nadir palmitate concentration (μmol/liter) | 12 ± 3 | 10 ± 4 | 15 ± 7 | 10 ± 4 | 0.244 | <0.001 | 0.062 |
| IVGTT nadir palmitate concentration (μmol/liter) | 13 ± 4 | 12 ± 4 | 18 ± 7 | 16 ± 8 | <0.001 | 0.043 | 0.807 |
| Meal nadir palmitate Ra (μmol/min) | 27 ± 9 | 22 ± 8 | 32 ± 13 | 20 ± 9 | 0.731 | <0.001 | 0.046 |
| IVGTT nadir palmitate Ra (μmol/min) | 32 ± 12 | 32 ± 13 | 40 ± 16 | 35 ± 15 | 0.012 | 0.112 | 0.359 |
Data are expressed as means ± sd. Differences by age group, sex, and the interaction were determined by two-way ANOVA. The palmitate Ra data are not adjusted for REE. For some variables, n = 30 for young males and n = 52 for elderly females.