Table 1.
Patient and corresponding PDECX mouse model information
|
Patient information |
|
Characterization & anti-tumor efficacy in the Patient-derived EC xenograft models |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
|
HER-2 |
Mutation |
Trastuzumab efficacy |
||||||||||
| Gender/age | Pathology | TNM stage | Grade | Model ID | FISH GCN | FISH Ratio (HER-2/CEP17) | IHC | PIK3CA | EGFR | K-ras | B-raf | TGI% | Tumor regression % | P value |
| M/70 |
ESCC |
IIIB |
Moderate |
EC004 |
1.52 |
1.07 |
- |
- |
- |
- |
- |
44 |
0 |
0.1333 |
| M/61 |
ESCC |
IIA |
Poor |
EC016 |
2.38 |
1.25 |
- |
- |
- |
- |
- |
0 |
0 |
0.3113 |
| M/65 |
ESCC |
IIA |
Moderate |
EC039 |
3.92 |
1.26 |
++ |
+ |
- |
- |
- |
41 |
0 |
0.2290 |
| M/56 |
ESCC |
IIIA |
Moderate |
EC044 |
3.90 |
1.55 |
++ |
- |
- |
- |
- |
>100 |
93 |
<0.0001 |
| M/73 | ESCC | IIIA | Moderate | EC054 | 3.04 | 1.27 | - | - | - | - | - | 48 | 0 | 0.0004 |