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. 2012 Sep 11;12:60. doi: 10.1186/1472-6750-12-60

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Copyright ©2012 DeCarlo et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Masson’s Trichrome stain, 12 wk healing.A: Left - TCP loaded and lyophilized with 50 μg/ml BMP-2. Right - B-247 treatment of TCP loaded and lyophilized with 50 μg/ml rhBMP-2 plus 100 μg/ml of pln.247 plasmid. Inset arrow designates region of panel B. B: 400x magnification of region designated in panel A between crest of ridge (towards left) and marrow space. Arrows designate remnant TCP particles which remain partially integrated with new bone (blue) after 12 weeks. C: Left - TCP loaded and lyophilized with 50 μg/ml BMP-2. Right - B-247 treatment of TCP loaded and lyophilized with 50 μg/ml rhBMP-2 plus 100 μg/ml of pln.247 plasmid. Pairs of images are from the same animal. Bar = 0.5 mm.