Effect of methotrexate and the combination of carnosine + methotrexate on adjuvant arthritis on the parameters of hind paw volume (HPV), activity of cellular γ-glutamyltransferase (GGT) in hind paw joint and spleen tissue homogenates and C-reactive protein (CRP) in plasma measured on day 28, expressed in percentage compared to the arthritis group considered as 100%.
AA – Adjuvant arthritis group (100%), AA- MTX – Adjuvant arthritis group administered methotrexate and AA-CARN+MTX – Adjuvant arthritis group administered with carnosine+methotrexate. Results are mean ± S.E.M., n=8–10. The symbol (+) shows significant difference +p<0.05 vs AA, ++p<0.01 vs AA, +++p<0.001 vs AA, ##p<0.01 vs AA-MTX.