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Functional activity of BAF312 on human S1P receptors in the GTPγ[35S] binding assay
| Receptor subtype | EC50 (nM) ± SD | %Emax |
|---|---|---|
| S1P1 | 0.39 ± 0.07 | 91 ± 6 |
| S1P2 | >10 000 | – |
| S1P3 | >1 000 | – |
| S1P4 | 750 ± 487 | 90 ± 9 |
| S1P5 | 0.98 ± 0.43 | 112 ± 20 |
EC50 values (nM; mean ± SD) and percentage of maximum stimulation (%Emax) induced by BAF312 on human S1P1, S1P2, S1P3, S1P4 and S1P5 receptors.
