Table 3.
Summary of associations between HLA-DRB1 alleles and pemphigus vulgaris
HLA-DRB1 type | Studies |
Allele counts |
Heterogeneity |
Model |
Association |
Sensitivity analysis |
Publication bias |
|||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Patients (n events/n total) | Controls (n events/n total) | χ2 | Ph | I2% | Pc | OR | 95% CI | Funnel plot | Begg’s test (Pr) | Egger’s test (P) | ||||
*01 | 9,10,12,13,15,28,31,33,34 | 27/730 | 166/2330 | 6·91 | 0·55 | 0 | Fixed | 0·002 | 0·50 | 0·33–0·77 | None | S | 0·902 | 0·795 |
*03 | 9,10,12,15,27,28,31–34 | 35/988 | 299/2690 | 8·65 | 0·47 | 0 | Fixed | < 0·00001 | 0·28 | 0·19–0·41 | None | S | 0·602 | 0·604 |
*04 | 9,10,12,13,15,27,28,30–34 | 366/1150 | 697/5397 | 66·31 | < 0·00001 | 83 | Random | < 0·00001 | 3·61 | 2·28–5·71 | None | S | 0·537 | 0·645 |
*07 | 9,10,12,27,28,31,33–35 | 55/962 | 289/2436 | 19·34 | 0·01 | 59 | Random | 0·004 | 0·45 | 0·26–0·78 | None | S | 0·754 | 0·864 |
*08 | 10,12,15,28,31,32,34 | 43/630 | 49/2724 | 12·94 | 0·04 | 54 | Random | 0·03 | 2·25 | 1·07–4·70 | Except15,31,32 | S | 1·000 | 0·873 |
*09 | 10,28,33,34 | 21/378 | 102/1200 | 2·70 | 0·44 | 0 | Fixed | 0·07 | 0·59 | 0·34–1·04 | None | S | 0·734 | 0·670 |
*10 | 10,12,15,28,33,34 | 6/538 | 44/1482 | 2·49 | 0·78 | 0 | Fixed | 0·09 | 0·48 | 0·21–1·12 | None | S | 0·296 | 0·512 |
*11 | 10,12,15,28,31,33,34 | 75/604 | 347/2000 | 2·51 | 0·87 | 0 | Fixed | < 0·00001 | 0·47 | 0·34–0·63 | None | S | 0·764 | 0·814 |
*12 | 10,12,15,28,33,34 | 19/538 | 71/1952 | 14·25 | 0·01 | 65 | Random | 0·83 | 0·88 | 0·27–2·83 | None | S | 1·000 | 0·668 |
*13 | 10,12,15,28,31,33,34 | 35/566 | 129/1504 | 2·51 | 0·87 | 0 | Fixed | 0·06 | 0·68 | 0·45–1·01 | Except12,34 | S | 1·000 | 0·654 |
*14 | 10,12,13,15,27,28,31–34 | 336/1048 | 199/3280 | 24·40 | 0·004 | 63 | Random | < 0·00001 | 6·47 | 4·52–9·26 | None | A | 0·049 | 0·034 |
*15 | 10,15,27,28,31,34 | 35/736 | 216/1594 | 10·43 | 0·06 | 52 | Random | 0·001 | 0·35 | 0·18–0·66 | None | S | 1·000 | 0·533 |
*16 | 10,15,28,34 | 9/402 | 56/1254 | 1·56 | 0·67 | 0 | Fixed | 0·05 | 0·47 | 0·23–0·98 | Except15,28,34 | S | 1·000 | 0·773 |
Ph, P-value for heterogeneity; Pc, P-value for comparability; OR, pooled odds ratio; CI, confidence interval; S, symmetrical; A, asymmetrical.