Table 2.

Selected disease associations of KIR3DS1.

Disease	Association when KIR3DS1 is present
Viral infections
HIV-1	Delayed progression to AIDS in combination with HLA-Bw4-I80 (Martin et al., 2002)
Hepatitis B virus infection	Increased rate of spontaneous recovery (Zhi-Ming et al., 2007)
H1N1 influenza A	Severe pandemic influenza A infections (Aranda-Romo et al., 2012)
Malignancies
Hepatocellular carcinoma	Reduced risk in combination with HLA-Bw4-I80 (Lopez-Vazquez et al., 2005)
Hodgkin’s lymphoma	Reduced risk (Besson et al., 2007)
Respiratory papillomatosis	Reduced risk (Bonagura et al., 2010)
Cervical neoplasia	Increased risk (Carrington et al., 2005)
Other
Allogeneic HSCT	Decreased progression-free survival of patients with multiple myeloma (Gabriel et al., 2010); decreased overall survival in HLA-Bw4− patients (Gagne et al., 2009); decreased acute GVHD (Venstrom et al., 2010)
Ankylosing spondylitis (AS)	Increased susceptibility for development of AS (Lopez-Larrea et al., 2006; Diaz-Pena et al., 2010)