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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Synlett. 2012 Oct;23(17):2539–2543. doi: 10.1055/s-0031-1290461

Table 1.

Conditions Attempted for Conversion of 7a into 8a Using CuI as Catalyst

Entry Solvent system Yield (%)a
1 DMF–t-BuOH (3:1), DIPEA 28
2 DMF–t-BuOH–H2O (3:1:1), DIPEA 0
3 DMF–t-BuOH (1:1), DIPEA 32
4 DMF, DIPEA 53
5 DMF, TMED 42
a

Yields were calculated after cleaving the resin (solvent MeOH–DCE = 1:1).