Table 2.
1,2,3-Triazole-Containing Farnesol Analogues
Entry | Compound | Structure | Yield (%)a | Purity LC–MS (%)b |
---|---|---|---|---|
1 | 4a |
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53 | 96 |
2 | 4b |
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55 | 89 |
3 | 4c |
![]() |
43 | 96 |
4 | 4d |
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36 | 88c |
5 | 4e |
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26 | 94c |
6 | 4f |
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57 | 90 |
7 | 4g |
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41 | 94 |
8 | 4h |
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32 | 98 |
9 | 4i |
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28 | 98 |
10 | 4j |
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38 | 94 |
11 | 4k |
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47 | 98 |
Yield (%) for 4a–k in two steps from 11. Dehydrated side products account for the bulk of the balance except for 4d and 4e.
The percentage was calculated by integrating HPLC chromatogram peaks at 230 nm.
Unidentified oxidized compounds [M + 16] account for the balance.