Table 8.
Experimental β-lactamase inhibitors active against carbapenemases from Enterobacteriaceae
| Inhibitor | Compound type | Inhibition spectrum (β-lactamase classes) | Susceptible carbapenemasesa | Reference(s) |
|---|---|---|---|---|
| BLI-489 | Penem | A, C, D | KPC type | 209 |
| J-110,411 and J-111,225 | 1-β-Methyl carbapenem | A, C, B | IMP type | 183, 184 |
| Mercaptomethyl sulfones | C-6-substituted penicillin sulfone | B | VIM and IMP types | 38 |
| 2,3-(S,S)-Disubstituted succinic acids | Succinic acid | B | IMP type | 170 |
| Thiomandelic acids | Thiol | B | VIM and IMP types | 147, 268 |
| Avibactam (NLX104) | Diazabicyclo-octanone | A, C, D | KPC type | 22 |
a
Only carbapenemase types with documented susceptibility to the respective inhibitor are included.