Table 2.
Genes and corresponding SNPs important in human WNV infection
| Gene(s) | SNP(s) | Comparison groups (n) | Study results | Reference |
|---|---|---|---|---|
| OASL | rs3213545 | WNV+ cases (33) vs healthy controls (16) | Associated with increased susceptibility to WNV infection | 236 |
| CCR5 | Δ32 deletion | WNV+ cases (395) vs WNV− (1,463) | Increased risk of symptomatic WNV infection | 69 |
| WNV+ cases (224) vs healthy controls (1,318) | Increased risk of symptomatic WNV infection | 113 | ||
| WNV+ cases (634) vs WNV− (422) | Not a risk factor for WNV initial infection; associated with symptomatic WNV infection | 114 | ||
| OAS1 | rs10774671 | WNV+ cases (501) vs healthy controls (552) | A risk factor for initial infection with WNV | 112 |
| IRF3, MX1, OAS1 | rs2304207, rs7280422, rs34137742 | Symptomatic cases (422) vs asymptomatic cases (331) | Associated with symptomatic WNV infection | 19 |
| RFC1, SCN1A, ANPEP | rs2066786, rs2298771, rs25651 | Severe WNV cases (560) vs mild WNV cases (950) | Associated with neuroinvasive disease in patients infected with WNV | 123 |