Table 2.
Regulation of immunopathology by helminth infections in micea
| Parasite and model | Mechanism type | Reference(s) |
|---|---|---|
| Fasciola hepatica | ||
| EAE | TGF–β dependent, IL–10 independent | 294 |
| Heligmosomoides polygyrus | ||
| Peanut-specific food allergy | IL-10 dependent | 23 |
| House dust mite-specific airway allergy | Treg dependent, IL-10 independent | 304 |
| Breg dependent, IL-10 independent | 305 | |
| OVA-specific airway allergy | Treg dependent, IL-10 independent?g | 111, 146, 304 |
| NOD diabetes | Treg and IL-10 independent | 167 |
| NOD diabetes | 247 | |
| EAE | Breg dependent (IL-10 independent) | 305 |
| TNBS colitis | 273 | |
| IL-10 dependent | 254 | |
| IL-10-deficient T cell transfer colitis | IL-10 independent | 107 |
| IL-10-deficient piroxicam-induced colitis | CD8+ cell dependent, IL-10 independent | 76, 199 |
| OVA-specific colitis | 163 | |
| Hymenolepis diminuta | ||
| Col II-specific arthritis | IL-4Rα, CD4, and IL-10 dependent | 256 |
| DNBS colitis | Macrophage and IL-10 dependent | 129, 130 |
| Litomosoides sigmodontis | ||
| OVA-specific airway allergyb | TGF-β and CD25+ Treg independent | 67 |
| NOD diabetes | TGF-β dependent; Th2, IL-10, and CD25+ Treg independent | 126, 127 |
| Nippostrongylus brasiliensis | ||
| OVA-specific airway allergyc | IL-10 dependent | 307 |
| Schistosoma japonicum | ||
| Col II-specific arthritisd | 114 | |
| TNBS colitis | 319 | |
| Schistosoma mansoni | ||
| Penicillin-specific anaphylaxisd | IL-10-producing Breg dependent; Treg, macrophage, and TGF-β independent | 185 |
| OVA-specific airway allergyd,e,f | CD1dhi B cell-dependent, IL-10-dependent expansion of Tregse | 186 |
| T or B cells transferred protection, IL-10 dependentd | 4e | |
| CD25+ Treg dependent (IL-10 independent)f | 260d | |
| 217d,f | ||
| NOD diabetesd,f | 50d | |
| NKT cell dependentf | 317f | |
| Col II-specific arthritisd | 215 | |
| DSS colitise | Macrophage and IL-10 dependent (but not alternatively activated macrophages) | 259 |
| TNBS colitise | 204 | |
| Symphacia obvelata | ||
| CFA-induced arthritis | 221 | |
| Trichinella spiralis | ||
| NOD diabetes | 247 | |
| DNBS colitis | 141 | |
| EAE | Dose dependent, transferred with splenocytes | 104, 105 |
a
EAE, experimental autoimmune encephalomyelitis; OVA, chicken egg ovalbumin; NOD, nonobese diabetic; TNBS, trinitrobenzene sulfonic acid; DNBS, dinitrobenzene sulfonic acid; TGF-β, transforming growth factor β; Treg, regulatory T cell; Breg, regulatory B cell; NKT, natural killer T; Col II, collagen II.
b
L. sigmodontis adults implanted into peritoneal cavity prior to OVA-alum injection.
c
Dependent on infection time: suppresses only when infection is prior to but not after sensitization.
d
Mixed-sex infection.
e
Male-only infection.
f
Egg injection.