Table 1.

Study schema^a

Groupb	Dose (IU)	No. of participantsc		Injection schedule in mo (days)
		US	SA	0	1 (28)	3 (84)
1	1 × 104	10	10	Vaccine	Vaccine	Vaccine
		2	2	Placebo	Placebo	Placebo
2	1 × 105	20	20	Vaccine	Vaccine	Vaccine
		4	4	Placebo	Placebo	Placebo
3	1 × 106	10	10	Vaccine	Vaccine	Vaccine
		2	2	Placebo	Placebo	Placebo
4	1 × 107	10	10	Vaccine	Vaccine	Vaccine
		2	2	Placebo	Placebo	Placebo
5	1 × 108	10	10	Vaccine	Vaccine	Vaccine
		2	2	Placebo	Placebo	Placebo

^aIU, infectious units; US, United States; SA, Southern Africa (South Africa and Botswana).

^bGroup 1 and half of group 2 were enrolled in HVTN 040; the remainder of group 2, as well as groups 3 to 5, was enrolled in HVTN 059.

^cThere were 72 participants (60 given the vaccine and 12 given the placebo) for each geographical group, for a total of 144 participants (120 given the vaccine and 24 given the placebo).