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. 2012 Oct;11(10):1289–1299. doi: 10.1128/EC.00215-12

Table 5.

Genes upregulated by at least 1.5-fold in strains carrying UPC2 GOF alleles

Functiona CGD name orf19 designation Change in expression (fold)b in indicated experiment
G648S
G648D
Y642F
A643V
1 2 1 2 1 2 1 2
Lipid metabolic process ERG1 orf19.406 1.8 1.8 2.7 2.3 2.2 2.0 2.3 2.3
ERG2 orf19.6026 1.7 1.5 2.3 1.9 1.9 1.9 2.1 2.0
ERG24 orf19.1598 1.7 1.7 2.3 2.1 1.7 1.8 2.1 2.3
ERG27 orf19.3240 1.8 2.1 3.3 3.4 2.2 2.2 3.1 3.2
ERG7 orf19.1570 1.5 1.6 2.8 2.1 1.8 1.6 2.7 2.4
NCP1 orf19.2672 1.6 1.7 2.6 2.0 1.7 1.9 1.9 1.9
orf19.3483 2.0 2.4 5.3 4.7 2.9 2.2 3.5 3.3
orf19.1881 1.5 1.6 2.4 2.2 1.5 1.5 2.4 2.1
orf19.6025 2.2 2.1 3.9 5.2 3.8 3.1 5.2 5.2
Transcription factor activity orf19.5210 1.5 2.1 2.7 2.7 1.8 1.5 2.9 2.3
Transport MDR1 orf19.5604 5.9 5.5 15.1 8.0 6.6 6.1 5.9 5.7
orf19.5535 1.5 1.6 2.2 2.7 1.5 1.9 2.7 3.2
FRP1 orf19.5634 5.4 5.7 17.3 17.5 8.1 5.9 16.3 14.7
FTH1 orf19.4802 2.6 2.6 5.3 5.2 2.3 1.9 6.6 5.2
GYP1 orf19.3811 1.6 1.6 3.7 3.5 1.8 1.5 3.7 3.4
orf19.2350 1.7 1.7 3.4 4.4 2.0 1.9 3.2 3.0
HXT5 orf19.4384 1.8 2.1 2.6 2.0 1.8 1.5 2.3 1.7
Protein modification process orf19.7329 1.6 2.1 3.1 3.0 1.7 1.8 2.5 2.3
orf19.6025 2.2 2.1 3.9 5.2 3.8 3.1 5.2 5.2
orf19.7547 1.8 1.5 2.8 2.7 2.0 1.5 3.1 2.3
orf19.2285 1.7 2.5 1.8 1.5 1.8 2.4 2.1 2.1
Biosynthetic Process COQ4 orf19.3008 1.5 1.5 2.3 2.8 1.9 1.6 2.6 2.5
HEM14 orf19.4747 2.1 1.6 3.6 3.0 2.2 1.8 2.9 2.3
Pathogenesis SLD1 orf19.260 1.8 1.5 2.2 1.8 1.7 1.6 2.0 1.9
PHO100 orf19.4424 1.5 3.4 4.8 2.7 1.6 1.5 2.0 2.3
SET3 orf19.7221 2.8 2.7 6.3 5.7 4.4 3.6 4.8 4.8
Metabolic process orf19.3617 1.7 1.9 1.7 2.2 1.7 1.5 1.8 1.5
orf19.329 2.1 2.3 2.4 2.6 2.0 1.6 2.5 2.5
orf19.4031 1.8 1.8 2.5 2.5 1.6 1.5 2.9 2.5
orf19.6025 2.2 2.1 3.9 5.2 3.8 3.1 5.2 5.2
orf19.1865 2.4 2.2 3.7 2.9 2.4 2.2 3.4 3.1
orf19.496 2.4 2.3 4.4 3.8 2.5 2.0 3.6 3.1
ARO9 orf19.1237 1.5 3.4 5.8 4.2 1.5 1.9 2.1 2.8
IDP2 orf19.3733 2.2 1.6 3.3 2.8 2.6 2.0 3.2 2.5
Response to stress DDR48 orf19.4082 2.2 4.3 5.8 4.7 2.7 2.9 3.4 4.3
FMA1 orf19.6837 1.8 3.2 2.7 5.3 1.5 3.3 1.7 3.0
YMX6 orf19.5713 1.6 2.6 2.9 2.0 1.6 1.6 1.7 1.8
orf19.288 1.8 1.5 3.0 2.5 2.1 1.5 2.5 2.0
Biological activity unknown TEF4 orf19.2652 16.4 16.6 55.8 90.2 29.9 32.7 65.5 67.8
orf19.3627 4.0 1.9 7.0 4.0 4.4 1.9 5.1 1.9
PGA7 orf19.5635 2.3 3.7 5.7 7.4 2.7 3.8 4.8 6.1
BUL1 orf19.5094 1.9 1.9 4.1 3.1 2.5 1.8 2.1 1.9
PGA45 orf19.2451 1.7 1.5 2.1 2.2 1.7 1.9 2.0 2.3
orf19.344 5.1 6.2 20.2 16.2 7.2 6.6 9.6 9.0
orf19.5777 1.7 2.4 4.8 3.8 1.9 1.5 3.1 2.5
orf19.5799 1.7 2.0 3.4 2.4 1.5 1.5 2.4 2.6
orf19.7456 1.7 2.6 4.4 4.1 2.2 2.1 3.9 3.5
orf19.7043 2.5 1.9 5.2 3.6 2.8 2.3 4.9 3.0
orf19.4013 2.6 2.2 4.2 3.5 3.1 2.8 4.8 3.8
orf19.4014 1.5 2.1 2.3 2.4 1.7 1.6 2.6 2.6
orf19.6840 2.0 2.1 4.1 4.4 2.6 2.4 3.1 2.6
orf19.286 2.1 2.5 2.3 2.2 1.9 1.9 3.5 1.9
orf19.7504 2.1 1.8 3.0 3.3 1.9 2.0 2.2 2.1
orf19.3737 1.6 1.9 2.9 3.4 2.0 1.8 3.1 2.6
orf19.1964 2.0 1.8 2.5 2.2 1.7 1.6 2.2 1.6
orf19.1800 2.3 2.2 4.6 3.9 2.5 2.2 4.5 3.4
orf19.7263 1.8 1.9 2.9 2.8 1.6 1.7 2.1 1.9
orf19.2496 1.7 1.8 2.6 2.5 1.8 1.7 2.0 1.5
ATO9 orf19.3261 1.8 2.2 2.7 3.4 1.6 2.3 4.5 4.5
a

Descriptions of genes are from the Candida Genome Database (http://www.candidagenome.org).

b

Fold change is defined as the average ratio of gene expression levels in the isolates compared in two independent microarray experiments.

HHS Vulnerability Disclosure