Table 5.
Genes upregulated by at least 1.5-fold in strains carrying UPC2 GOF alleles
Functiona | CGD name | orf19 designation | Change in expression (fold)b in indicated experiment |
|||||||
---|---|---|---|---|---|---|---|---|---|---|
G648S |
G648D |
Y642F |
A643V |
|||||||
1 | 2 | 1 | 2 | 1 | 2 | 1 | 2 | |||
Lipid metabolic process | ERG1 | orf19.406 | 1.8 | 1.8 | 2.7 | 2.3 | 2.2 | 2.0 | 2.3 | 2.3 |
ERG2 | orf19.6026 | 1.7 | 1.5 | 2.3 | 1.9 | 1.9 | 1.9 | 2.1 | 2.0 | |
ERG24 | orf19.1598 | 1.7 | 1.7 | 2.3 | 2.1 | 1.7 | 1.8 | 2.1 | 2.3 | |
ERG27 | orf19.3240 | 1.8 | 2.1 | 3.3 | 3.4 | 2.2 | 2.2 | 3.1 | 3.2 | |
ERG7 | orf19.1570 | 1.5 | 1.6 | 2.8 | 2.1 | 1.8 | 1.6 | 2.7 | 2.4 | |
NCP1 | orf19.2672 | 1.6 | 1.7 | 2.6 | 2.0 | 1.7 | 1.9 | 1.9 | 1.9 | |
orf19.3483 | 2.0 | 2.4 | 5.3 | 4.7 | 2.9 | 2.2 | 3.5 | 3.3 | ||
orf19.1881 | 1.5 | 1.6 | 2.4 | 2.2 | 1.5 | 1.5 | 2.4 | 2.1 | ||
orf19.6025 | 2.2 | 2.1 | 3.9 | 5.2 | 3.8 | 3.1 | 5.2 | 5.2 | ||
Transcription factor activity | orf19.5210 | 1.5 | 2.1 | 2.7 | 2.7 | 1.8 | 1.5 | 2.9 | 2.3 | |
Transport | MDR1 | orf19.5604 | 5.9 | 5.5 | 15.1 | 8.0 | 6.6 | 6.1 | 5.9 | 5.7 |
orf19.5535 | 1.5 | 1.6 | 2.2 | 2.7 | 1.5 | 1.9 | 2.7 | 3.2 | ||
FRP1 | orf19.5634 | 5.4 | 5.7 | 17.3 | 17.5 | 8.1 | 5.9 | 16.3 | 14.7 | |
FTH1 | orf19.4802 | 2.6 | 2.6 | 5.3 | 5.2 | 2.3 | 1.9 | 6.6 | 5.2 | |
GYP1 | orf19.3811 | 1.6 | 1.6 | 3.7 | 3.5 | 1.8 | 1.5 | 3.7 | 3.4 | |
orf19.2350 | 1.7 | 1.7 | 3.4 | 4.4 | 2.0 | 1.9 | 3.2 | 3.0 | ||
HXT5 | orf19.4384 | 1.8 | 2.1 | 2.6 | 2.0 | 1.8 | 1.5 | 2.3 | 1.7 | |
Protein modification process | orf19.7329 | 1.6 | 2.1 | 3.1 | 3.0 | 1.7 | 1.8 | 2.5 | 2.3 | |
orf19.6025 | 2.2 | 2.1 | 3.9 | 5.2 | 3.8 | 3.1 | 5.2 | 5.2 | ||
orf19.7547 | 1.8 | 1.5 | 2.8 | 2.7 | 2.0 | 1.5 | 3.1 | 2.3 | ||
orf19.2285 | 1.7 | 2.5 | 1.8 | 1.5 | 1.8 | 2.4 | 2.1 | 2.1 | ||
Biosynthetic Process | COQ4 | orf19.3008 | 1.5 | 1.5 | 2.3 | 2.8 | 1.9 | 1.6 | 2.6 | 2.5 |
HEM14 | orf19.4747 | 2.1 | 1.6 | 3.6 | 3.0 | 2.2 | 1.8 | 2.9 | 2.3 | |
Pathogenesis | SLD1 | orf19.260 | 1.8 | 1.5 | 2.2 | 1.8 | 1.7 | 1.6 | 2.0 | 1.9 |
PHO100 | orf19.4424 | 1.5 | 3.4 | 4.8 | 2.7 | 1.6 | 1.5 | 2.0 | 2.3 | |
SET3 | orf19.7221 | 2.8 | 2.7 | 6.3 | 5.7 | 4.4 | 3.6 | 4.8 | 4.8 | |
Metabolic process | orf19.3617 | 1.7 | 1.9 | 1.7 | 2.2 | 1.7 | 1.5 | 1.8 | 1.5 | |
orf19.329 | 2.1 | 2.3 | 2.4 | 2.6 | 2.0 | 1.6 | 2.5 | 2.5 | ||
orf19.4031 | 1.8 | 1.8 | 2.5 | 2.5 | 1.6 | 1.5 | 2.9 | 2.5 | ||
orf19.6025 | 2.2 | 2.1 | 3.9 | 5.2 | 3.8 | 3.1 | 5.2 | 5.2 | ||
orf19.1865 | 2.4 | 2.2 | 3.7 | 2.9 | 2.4 | 2.2 | 3.4 | 3.1 | ||
orf19.496 | 2.4 | 2.3 | 4.4 | 3.8 | 2.5 | 2.0 | 3.6 | 3.1 | ||
ARO9 | orf19.1237 | 1.5 | 3.4 | 5.8 | 4.2 | 1.5 | 1.9 | 2.1 | 2.8 | |
IDP2 | orf19.3733 | 2.2 | 1.6 | 3.3 | 2.8 | 2.6 | 2.0 | 3.2 | 2.5 | |
Response to stress | DDR48 | orf19.4082 | 2.2 | 4.3 | 5.8 | 4.7 | 2.7 | 2.9 | 3.4 | 4.3 |
FMA1 | orf19.6837 | 1.8 | 3.2 | 2.7 | 5.3 | 1.5 | 3.3 | 1.7 | 3.0 | |
YMX6 | orf19.5713 | 1.6 | 2.6 | 2.9 | 2.0 | 1.6 | 1.6 | 1.7 | 1.8 | |
orf19.288 | 1.8 | 1.5 | 3.0 | 2.5 | 2.1 | 1.5 | 2.5 | 2.0 | ||
Biological activity unknown | TEF4 | orf19.2652 | 16.4 | 16.6 | 55.8 | 90.2 | 29.9 | 32.7 | 65.5 | 67.8 |
orf19.3627 | 4.0 | 1.9 | 7.0 | 4.0 | 4.4 | 1.9 | 5.1 | 1.9 | ||
PGA7 | orf19.5635 | 2.3 | 3.7 | 5.7 | 7.4 | 2.7 | 3.8 | 4.8 | 6.1 | |
BUL1 | orf19.5094 | 1.9 | 1.9 | 4.1 | 3.1 | 2.5 | 1.8 | 2.1 | 1.9 | |
PGA45 | orf19.2451 | 1.7 | 1.5 | 2.1 | 2.2 | 1.7 | 1.9 | 2.0 | 2.3 | |
orf19.344 | 5.1 | 6.2 | 20.2 | 16.2 | 7.2 | 6.6 | 9.6 | 9.0 | ||
orf19.5777 | 1.7 | 2.4 | 4.8 | 3.8 | 1.9 | 1.5 | 3.1 | 2.5 | ||
orf19.5799 | 1.7 | 2.0 | 3.4 | 2.4 | 1.5 | 1.5 | 2.4 | 2.6 | ||
orf19.7456 | 1.7 | 2.6 | 4.4 | 4.1 | 2.2 | 2.1 | 3.9 | 3.5 | ||
orf19.7043 | 2.5 | 1.9 | 5.2 | 3.6 | 2.8 | 2.3 | 4.9 | 3.0 | ||
orf19.4013 | 2.6 | 2.2 | 4.2 | 3.5 | 3.1 | 2.8 | 4.8 | 3.8 | ||
orf19.4014 | 1.5 | 2.1 | 2.3 | 2.4 | 1.7 | 1.6 | 2.6 | 2.6 | ||
orf19.6840 | 2.0 | 2.1 | 4.1 | 4.4 | 2.6 | 2.4 | 3.1 | 2.6 | ||
orf19.286 | 2.1 | 2.5 | 2.3 | 2.2 | 1.9 | 1.9 | 3.5 | 1.9 | ||
orf19.7504 | 2.1 | 1.8 | 3.0 | 3.3 | 1.9 | 2.0 | 2.2 | 2.1 | ||
orf19.3737 | 1.6 | 1.9 | 2.9 | 3.4 | 2.0 | 1.8 | 3.1 | 2.6 | ||
orf19.1964 | 2.0 | 1.8 | 2.5 | 2.2 | 1.7 | 1.6 | 2.2 | 1.6 | ||
orf19.1800 | 2.3 | 2.2 | 4.6 | 3.9 | 2.5 | 2.2 | 4.5 | 3.4 | ||
orf19.7263 | 1.8 | 1.9 | 2.9 | 2.8 | 1.6 | 1.7 | 2.1 | 1.9 | ||
orf19.2496 | 1.7 | 1.8 | 2.6 | 2.5 | 1.8 | 1.7 | 2.0 | 1.5 | ||
ATO9 | orf19.3261 | 1.8 | 2.2 | 2.7 | 3.4 | 1.6 | 2.3 | 4.5 | 4.5 |
Descriptions of genes are from the Candida Genome Database (http://www.candidagenome.org).
Fold change is defined as the average ratio of gene expression levels in the isolates compared in two independent microarray experiments.