Table 6.
Genes downregulated by at least 1.5-fold in strains carrying UPC2 GOF alleles
Functiona | CGD name | orf19 designation | Change in expression (fold)b in indicated experiment |
|||||||
---|---|---|---|---|---|---|---|---|---|---|
G648S |
G648D |
Y642F |
A643V |
|||||||
1 | 2 | 1 | 2 | 1 | 2 | 1 | 2 | |||
Transport | HGT10 | orf19.5753 | 0.6 | 0.5 | 0.2 | 0.2 | 0.5 | 0.6 | 0.2 | 0.3 |
Pathogenesis | SAP7 | orf19.756 | 0.4 | 0.4 | 0.3 | 0.2 | 0.4 | 0.4 | 0.3 | 0.4 |
Biological activity unknown | orf19.716 | 0.4 | 0.5 | 0.4 | 0.4 | 0.6 | 0.6 | 0.4 | 0.4 | |
orf19.3621 | 0.3 | 0.5 | 0.3 | 0.3 | 0.6 | 0.4 | 0.5 | 0.5 | ||
orf19.4873 | 0.4 | 0.5 | 0.6 | 0.5 | 0.6 | 0.6 | 0.6 | 0.6 |
Descriptions of genes are from the Candida Genome Database (http://www.candidagenome.org).
Fold change is defined as the average ratio of gene expression levels in the isolates compared in two independent microarray experiments.