Kinetic profiles of cell growth (A), content of ganoderic acids (B), and accumulation of squalene (C) and lanosterol (D) in the wild-type strain (○), the strain transformed with pJW (□), and the tHMGR overexpressed strain (△). The error bars indicate the standard deviations from three independent samples. *, statistical significance (P < 0.05) compared to the WT strain. d, days.