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Leptospira katE mutants are attenuated in hamsters. All animals infected with wild-type strains of L. interrogans serovars Pomona (A) and Manilae (B) displayed disease symptoms, and all were euthanized by 19 days postinfection. Animals infected with mutant strains P3 (A) and m69 (B) did not display disease symptoms and exhibited 100% survival at 21 days postinfection (P ≤ 0.0007 by Fisher's exact test).
