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TLR4 mRNA expression. (a) Expression of TLR4 mRNA by TECs from TIR8+/+ and TIR8−/− mice stimulated with LPS or heat-killed (HK) uropathogenic bacteria. Data are means ± SEM (n = 5 per group). (b) TLR4 mRNA expression in kidneys from TIR8+/+ and TIR8−/− mice with upper urinary tract infection as determined by semiquantitative PCR. Data are means and SEM of 6 to 8 mice per group.
