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Farnesyltransferase regulates CXC chemokine formation in the lung. Animals were treated with FTI-277 (2.5 or 25 mg/kg) or vehicle (PBS) 10 min prior to M1 protein injection. Mice treated with PBS served as sham-treated animals. ELISA was used to quantify the levels of CXCL1 (A) and CXCL2 (B) in the lungs of mice 4 h after M1 protein challenge. Data represent means ± SEM (n = 5). *, P < 0.05 versus results of sham treatment; #, P < 0.05 versus results of vehicle + M1 protein.
