Table 4.

Network generation of genes downregulated by N. meningitidis and upregulated by IL-10^a

Network	Molecules in networkb	Scorec	Top functions
1	ARNTL2, BCL3, BCL2L11, CCND2, CCR5, CD36, CD38, CDKN1B, CISH, CRK, FCER1G, FKBP1A, FURIN, GNA15, HCK, IFNAR1, IL-13, IL13RA1, LDHA, LILRB2, LTBR, MAOA, MRC1, NLRC4, NOS2, PRELID1, RAC1, RAC2, RHOA, STAT4, STAT6, SWAP70, SYK, TYK2, VAV1	16	Cell death, cellular growth and proliferation, hematological system development and function
2	ARRDC4, CBL, CCL2, CCL3, CCR5, CD19, CD28, CSF1R, CTSB, CXCL16, DAB2, DTNBP1, FPR2, FYN, GAB2, IFNAR1, IL-6, IL10RB, IL-15, IL17RA, IRF5, IRF8, KHDRBS1, LAT, PAG1, PRKCQ, PTGS2, PTPN2, PTPN11, PTTG1IP, RASA1, STAT3, THBD, TREM, VCAN	16	Hematological system development and function, tissue morphology and inflammatory response
3	AKT1, ANXA4, AP3B1, ARRB2, B3GNT2, CBLB, CCL1, CCL3, CD14, CEBPE, CHUK, CISH, DICER1, FPR1, GCLM, GSTA1, IL1A, IL1R1, IL1R2, IL1RAP, INPP5D, IRAK4, LAIR1, LILRA2, MAP3K7, NFE2L2, NFKBIB, NQ01, PLAGL2, SFTPD, TLR1, TNF, TNFRSF1A, TRAF2	12	Inflammatory response, cellular movement, hematological system development and function

^aGene networks were generated based on existing scientific information about the molecular relationships between genes and gene products in the Ingenuity Knowledge Base.

^bGenes in bold are the focus molecules which were significantly downregulated by N. meningitidis and upregulated by IL-10.

^cThe score indicates the likelihood that the relationships in the network could be explained by chance alone. A score of 2 would indicate that there is a 10⁻² probability that the focus molecules are in a network together by chance.