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. 2012 Nov;80(11):3869–3879. doi: 10.1128/IAI.00435-12

Fig 7.

Fig 7

AgI/II adhesin sequence types. (A) Neighboring-joining tree from the AgI/II full-gene sequences showing a diversity of AgI/II adhesin sequence types (AgI/II STs 1 to 18) between human hosts (n = 19 subjects) of defined caries, PRP, and adhesion phenotypes. The bars indicate the number of base differences per sequence. (B) Schematic picture of the AgI/II amino acid variations and substitutions related to each AgI/II adhesin sequence type (a solid vertical line marks each amino acid substitution). The leader peptide (LP), alanine-rich repeats (A), variable domain (V), proline-rich domain (P), and cell wall anchorage (CWA) region are marked. (C) Relative avidity of adhesion of independent isolates (n = 19 or n = 70) with AgI/II type A or B to gp340 (2.5 and 5.0 μg) or matched saliva, unadjusted or adjusted for the expression level of AgI/II. Adhesion (%) indicates the percentage of adhering cells out of the total cells added. P values derived by a Mann-Whitney test are given.