Fig 7.
Integration and excision dynamics of MGIs in donor and recipient cells. (A) Excision from the donor cell chromosome. (1) SOS response is activated by DNA damages, alleviating the SetR-mediated repression of setCD. (2) The transcriptional activator SetCD activates the expression of intMGI and rdfM. (3) IntMGI and RdfM mediate the excision of the MGI. (B) Integration into the recipient cell chromosome. intMGI is expressed at a low level and allows MGI integration regardless of the presence or absence of an SXT/R391 ICE.