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Simplified scheme of de novo dTMP synthesis. De novo synthesis of dCDP is catalyzed by ribonucleotide reductase. Conversion of dCMP to dUMP is catalyzed by dCMP deaminase, which is positively regulated by dCTP (+) and inhibited by dTTP (−). Red arrows indicate the major dTTP synthesis pathway via dCMP deaminase, and blue arrows indicate the minor dTTP synthesis pathway via dUTPase.
