Table 2.
Effects, relative to basal, of CGS21680, 8-Br-cAMP and XAC on parameters measured in differentiated SH cells
| Parameter | CGS21680 | 8-Br-cAMP | XAC |
|---|---|---|---|
| Cyclic AMP | 5.6-fold (4.9–6.4-fold) | n.d. | 61 % (41–81 %) |
| Noradrenaline release | 114 % (105–122 %) | 55 % (38–72 %) | 80 % (69–91 %) |
| VDCC | 101.9 ± 25.4 % | 76.9 ± 16.4 % | n.d. |
| CREB phosphorylation | 253 ± 65 % | 140 ± 32 % | No effecta |
| Rabphilin phosphorylation | 230 ± 58 % | 132 ± 35 % | No effecta |
| Protein–tyrosine phosphorylation | 168 ± 50 % | 246 ± 84 % | No effecta |
Effects presented in Figs. 1, 2, 3, 4, 5, 6 and 7 are expressed as percent of the appropriate basal value (except for cAMP in the presence of CGS21680)
aRepeated observations indicated that the amount of phospho-protein obtained in the presence of XAC was indistinguishable from basal (experiments performed in the presence of adenosine deaminase); 99 % confidence intervals are given in brackets, standard deviation as ±values. Statistical evaluation of differences is reported in the figure legends