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. 2012 Nov;32(22):4595–4610. doi: 10.1128/MCB.00724-12

Fig 7.

Fig 7

USF2 is critical for CBP and p300 protein recruitment to HIF2 target genes (PAI1 and EPO) in vivo. ChIP analysis of Pol II, CBP, p300, USF2, and HIF2α binding to the HIF2 target gene PAI1 promoter at the region close to the transcription start site and HRE (PAI1 from positions −248 to −128) (A), the PAI promoter away from the transcription start site and HRE (PAI1 from positions −808 to −608) (B), the HIF2 target gene EPO promoter close to the EPO transcription start site (EPO from positions −128 to −23) (C), and the EPO enhancer that is close to the validated HRE (EPO from positions +2970 to +3058) (D) in normoxic (Nx) or hypoxic (Hx) parental Hep3B, Hep3B/ARNT shRNA, or Hep3B/USF2 shRNA cells. No Chro., no chromatin.