Table 2.

In vitro susceptibilities of all 2008–2011 surveillance Candida isolates

Species (no. of isolates)	Antifungal agent	MIC (μg/ml)			% Resistant isolates (no.)
		Range	MIC50	MIC90
All isolates (2,329)	Fluconazole	0.125–256	1	16	7.3 (165)
	Voriconazole	0.008–16	0.06	0.25	1.0 (16)
	Itraconazole	0.015–16	0.25	1	21.1 (493)
	Posaconazole	0.008–16	0.125	1
	Caspofungin	0.008–16	0.06	0.25	1.0 (22)
	Anidulafungin	0.008–4	0.03	1	1.0 (23)
	Micafungin	0.008–4	0.03	1	1.1 (25)
	Flucytosine	0.125–256	0.125	1	0.8 (19)
	Amphotericin B	0.002–2	0.125	0.38
C. albicans (877)	Fluconazole	0.125–256	0.5	1	2.3
	Voriconazole	0.008–16	0.03	0.125	0.9
	Itraconazole	0.03–16	0.125	0.25	1.6
	Posaconazole	0.008–16	0.125	0.25
	Caspofungin	0.008–2	0.03	0.06	0.5
	Anidulafungin	0.008–2	0.015	0.06	0.3
	Micafungin	0.008–2	0.03	0.03	0.3
	Flucytosine	0.125–256	0.25	2	0.9
	Amphotericin B	0.002–0.5	0.094	0.19
C. glabrata (670)	Fluconazole	0.5–256	8	64	11.9
	Voriconazolea	0.008–16	0.25	2
	Itraconazole	0.06–16	1	4	59.6
	Posaconazole	0.008–16	0.5	2
	Caspofungin	0.015–16	0.06	0.125	2.4
	Anidulafungin	0.008–4	0.06	0.125	2.7
	Micafungin	0.008–4	0.015	0.03	2.7
	Flucytosine	0.125–256	0.125	0.125	0.6
	Amphotericin B	0.002–2	0.25	0.5
C. parapsilosis (389)	Fluconazole	0.125–64	1	2	4.1
	Voriconazole	0.008–2	0.03	0.06	0.8
	Itraconazole	0.015–1	0.25	0.5	1.5
	Posaconazole	0.008–1	0.125	0.25
	Caspofungin	0.008–2	0.25	0.5	0
	Anidulafungin	0.008–8	1	2	0.3
	Micafungin	0.008–4	1	2	0
	Flucytosine	0.125–8	0.125	0.25	0
	Amphotericin B	0.002–2	0.064	0.19
C. tropicalis (241)	Fluconazole	0.125–128	0.5	2	6.2
	Voriconazole	0.008–16	0.06	0.125	2.5
	Itraconazole	0.015–16	0.5	1	22.4
	Posaconazole	0.008–1	0.125	0.5
	Caspofungin	0.008–2	0.03	0.125	0.8
	Anidulafungin	0.008–0.25	0.015	0.06	0
	Micafungin	0.008–1	0.03	0.125	1.2
	Flucytosine	0.125–128	0.125	0.25	1.7
	Amphotericin B	0.008–1	0.25	0.5
C. dubliniensis (36)a	Fluconazole	0.125–16	0.25	0.5	5.6
	Voriconazole	0.008–0.125	0.015	0.03	0
	Itraconazole	0.03–0.5	0.125	0.25	0
	Posaconazole	0.03–0.25	0.06	0.125
	Caspofungin	0.03–0.25	0.06	0.125	0
	Anidulafungin	0.015–1	0.03	0.06	2.8
	Micafungin	0.008–1	0.06	0.06	2.8
	Flucytosine	0.125–0.25	0.125	0.125	0
	Amphotericin B	0.006–0.125	0.023	0.064
C. lusitaniae (34)	Fluconazole	0.125–8	0.5	1
	Voriconazole	0.008–0.015	0.008	0.015
	Itraconazole	0.03–1	0.25	0.5
	Posaconazole	0.03–0.5	0.125	0.25
	Caspofungin	0.03–1	0.25	0.5
	Anidulafungin	0.008–1	0.25	0.5
	Micafungin	0.015–2	0.25	0.5
	Flucytosine	0.125–128	0.125	2
	Amphotericin B	0.016–0.38	0.064	0.125
C. krusei (32)	Fluconazoleb	4–64	16	64	100
	Voriconazole	0.015–0.5	0.25	0.25	0
	Itraconazole	0.125–2	0.5	1	21.9
	Posaconazole	0.125–1	0.25	0.5
	Caspofungin	0.06–0.5	0.125	0.25	0
	Anidulafungin	0.015–0.25	0.03	0.06	0
	Micafungin	0.06–0.125	0.125	0.125	0
	Flucytosine	4–64	8	16	6.3
	Amphotericin B	0.023–1	0.5	0.75
Other species (50)	Fluconazolea	0.25–16	2	8
	Voriconazolea	0.008–0.25	0.06	0.25
	Itraconazolea	0.06–2	0.25	1	18.0
	Posaconazole	0.03–2	0.25	0.5
	Caspofungin	0.03–0.5	0.125	0.5
	Anidulafungin	0.015–2	0.25	1
	Micafungin	0.008–2	0.25	1
	Flucytosine	0.125–8	0.125	0.25	0
	Amphotericin B	0.002–1	0.064	0.5

^aC. albicans breakpoints were applied.

^bPercent resistant was based on intrinsic resistance of C. krusei and did not follow actual MICs.