Table 2.
Direct comparisons of PCR and GM
| Comparison (no. of studies) | Sensitivity (%) (95% CI) | Specificity (%) (95% CI) | DOR (95% CI) | P value |
|---|---|---|---|---|
| PCR vs GM with an ODI of >0.5 (7) | 0.088 | |||
| PCR | 86.4 (68.2–95) | 96.2 (90.2–98.6) | 163 (47–560) | |
| GM | 82 (52.7–94.9) | 96.6 (92.2–98.6) | 129 (32–516) | |
| PCR vs GM with an ODI of >1.0 (7) | 0.01 | |||
| PCR | 92.6 (69.9–98.5) | 97.7 (92.6–99.3) | 516 (82–3,248) | |
| GM | 85.1 (62.5–95.1) | 99.7 (97.3–100) | 1,731 (202–14,802) | |
| Any positive result vs GM (10)a | 0.001 | |||
| GM or PCR | 97 (83–99.5) | 97.5 (92.9–99.1) | 1,258 (155–10,215) | |
| GM | 89 (63–97.5) | 98.5 (94.5–99.6) | 516 (74–3,611) |
a
Comparison between a positive result defined by either PCR or GM positivity when both tests are performed and GM alone. Paired analysis was conducted with all studies reporting on GM in BAL fluid preferably using the results obtained with an ODI cutoff of >0.5.