Table 3.
Comparison of published Xpert vanA/vanB test characteristicsa
| Study | No. of specimens tested | VRE prevalence | VRE positivity rate | Gene target | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|---|
| Marner et al. (16)b,c | 184 | 46.7 | NA | vanA/vanB | 96.4 (89.6–99.2) | 93.0 (86.0–96.8) | 92.0 (84.2–96.3) | 96.9 (86.5–99.4) |
| This study | 300 | 30.0 | NA | vanA | 100 (95.1–100) | 96 (93.7–98.8) | 91.4 (83.0–96.5) | 100 (98.3–100) |
| Bourdon et al. (5) | 804 | NA | 1.4 | vanA | 100 (62.8–100) | 99.5 (98.7–99.9) | 66.7 (38.8–86.5) | 100 (99.4–100) |
| vanB | 100 (38.2–100) | 85.6 (82.9–87.8) | 2.6 (0.6–7.7) | 100 (99.3–100) | ||||
| Dekeyser et al. (9) | 447 | 1.0 | NA | vanA/vanB | 100 (ND) | 76.8 (ND) | 2.8 (ND) | 100 (ND) |
| 118 | 5.9 | NA | vanA/vanB | 100 (ND) | 69.3 (ND) | 15 (ND) | 100 (ND) | |
| Gazin et al. (11)b,d | 50 | NA | 44 | vanA | 73.9 (ND) | 92.3 (ND) | 89.5 (ND) | 80.6 (ND) |
| vanB | 87.5 (ND) | 14.7 (ND) | 32.6 (ND) | 71.4 (ND) | ||||
| Zabicka et al. (23)d | 37 | 35.1 | NA | vanA/vanB | 61.5 (32.3–84.8) | 79.2 (57.3–92.1) | 61.5 (32.3–84.9) | 79.2 (57.3–92.1) |
a
PPV, positive predictive value; NPV, negative predictive value; ND, not determined; NA, not available. Values in parentheses are the 95% confidence interval.
b
Study not done on consecutive specimens. When prevalence was not available, the positivity rate obtained with the culture method is listed.
c
Perianal swab specimens.
d
Stool specimens.