Fig. 4.

Gray level co-occurrence matrix (GLCM) and Fourier transform (FT) texture analyses of Col1 fibers in primary breast tumors were able to distinguish between ${\mathrm{LN}}^{+}$ and ${\mathrm{LN}}^{-}$ patients. (a), GLCM parameters showed that ${\mathrm{LN}}^{-}$ patients ($n=6$) displayed a significantly decreased inter-fiber co-relation ($P=0.0007$) and significantly higher energy uniformity ($P=0.0178$) compared to ${\mathrm{LN}}^{+}$ patients ($n=8$). (b), Texture analysis using FT demonstrated that the Col1 fiber distribution of ${\mathrm{LN}}^{-}$ patients ($n=6$) had a significantly higher aspect ratio (AR, $P=0.0557$) and significantly higher eccentricity value ($P=0.0462$) compared to ${\mathrm{LN}}^{+}$ patients ($n=8$). Values are $\text{mean}\pm \text{standard deviation}$.