Fig 6.

Cross-neutralizing immune responses against cell culture-replicating HCV. Huh-7.5 cells were infected with an MOI of 0.1. The first and second sets of 3 columns show neutralization with control antibodies anti-CD81 and anti-E2. Levels of neutralization of chimeric HCVcc containing structural proteins are indicated as follows: H77 (genotype 1a) with black columns, Con1 (genotype 1b) with dark gray columns, and J6 (genotype 2a) with light gray columns. Other sets of columns show neutralization levels observed in sera of 5 mice primed with control MVvac2, 8 mice primed with MV-E1/Ft-E2/Ft, or 8 mice primed with MV-CE1E2. All mouse serum samples were diluted 1:200. At the bottom is shown the statistical significance of the differences observed between the groups, using the same color-coding of the chimeric HCVcc genotypes as for the neutralization assay.